CYCLIC HOMOPENTAPEPTIDES .2. SYNTHETIC MODIFICATIONS OF VIOMYCIN

Authors
LYSSIKATOS JP CHANG SP CLANCY J DIRLAM JP FINEGAN SM GIRARD AE HAYASHI SF LARSON DP LEE AS LINDE RG MACLELLAND CP PETITPAS JW SEIBEL SB VU CB
Citation
Jp. Lyssikatos et al., CYCLIC HOMOPENTAPEPTIDES .2. SYNTHETIC MODIFICATIONS OF VIOMYCIN, Bioorganic & medicinal chemistry letters, 7(9), 1997, pp. 1145-1148
Citations number
1
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
9
Year of publication
1997
Pages
1145 - 1148
Database
ISI
SICI code
0960-894X(1997)7:9<1145:CH.SMO>2.0.ZU;2-R
Abstract
This paper describes synthetic modifications of the C-19 position of t uberactinomycin B (viomycin) and related analogs. The in vitro antibac terial activity of selected analogs against Pasteurella multocida. Esc herichia coil and methicillin-resistant Staphylococcus aureus is also discussed. Although C-19 arylation and thiolation did not improve anti bacterial activity, C-19 benzyl carbamates, benzyl- and phenyl ureas w ere found to be more potent than the parent antibiotic. (C) 1997 Elsev ier Science Ltd.