STRUCTURE-ACTIVITY STUDIES OF ARYL-SPACED DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AMPA RECEPTOR ANTAGONISTS

Authors
BLEISCH TJ ORNSTEIN PL ALLEN NK WRIGHT RA LODGE D SCHOEPP DD
Citation
Tj. Bleisch et al., STRUCTURE-ACTIVITY STUDIES OF ARYL-SPACED DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AMPA RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 7(9), 1997, pp. 1161-1166
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
9
Year of publication
1997
Pages
1161 - 1166
Database
ISI
SICI code
0960-894X(1997)7:9<1161:SSOAD>2.0.ZU;2-#
Abstract
We report the synthesis and structure activity studies of a series of decahydroisoquinoline AMPA antagonists where the distal acid is joined to the bicyclic ring nucleus with a spacer that contains an aromatic ring. These phenyl and thienyl substituted compounds are characterized as relatively potent AMPA antagoinsts. (C) 1997 Elsevier Science Ltd.