A FACILE ROUTE TO 3'-MODIFIED OLIGONUCLEOTIDES

Authors
SHCHEPINOV MS STETSENKO DA
Citation
Ms. Shchepinov et Da. Stetsenko, A FACILE ROUTE TO 3'-MODIFIED OLIGONUCLEOTIDES, Bioorganic & medicinal chemistry letters, 7(9), 1997, pp. 1181-1184
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
9
Year of publication
1997
Pages
1181 - 1184
Database
ISI
SICI code
0960-894X(1997)7:9<1181:AFRT3O>2.0.ZU;2-F
Abstract
We describe an easy method for the solid phase synthesis of 3'-modifie d oligonucleotides. The general synthetic scheme involves the immobili sation of 5'-DMTr-T to CPG via a sulfonate linker, oligonucleotide syn thesis and subsequent basic treatment to afford 3'-modified oligonucle otides containing a 2,3'-anhydronucleoside moiety. These compounds can be readily transformed into 3'-substituted oligonucleotides such as 3 '-deoxy-3'-azido species. (C) 1997 Elsevier Science Ltd.