SYNTHESIS AND BIOLOGICAL-ACTIVITY OF CYCLIC ANALOGS OF MPPG AND MCPG AS METABOTROPIC GLUTAMATE-RECEPTOR ANTAGONISTS

Authors
MA DW TIAN HQ SUN HB KOZIKOWSKI AP PSHENICHKIN S WROBLEWSKI JT
Citation
Dw. Ma et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF CYCLIC ANALOGS OF MPPG AND MCPG AS METABOTROPIC GLUTAMATE-RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 7(9), 1997, pp. 1195-1198
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
9
Year of publication
1997
Pages
1195 - 1198
Database
ISI
SICI code
0960-894X(1997)7:9<1195:SABOCA>2.0.ZU;2-W
Abstract
The synthesis of two rigidified phenylglycine analogues is disclosed. The cyclic analogue 1 of (R,S)-alpha-methyl-4-phosphonophenylglycine ( MPPG) is shown to be a particularly interesting pharmacological tool, for it is a group II selective mGluR antagonist that possesses an inve rse agonist-like action