AN EFFICIENT SYNTHESIS OF DES-N-METHYL-N-ACETYL ERYTHROMYCIN DERIVATIVES VIA THE N-OXIDE

Authors
KU YY RILEY D PATEL H YANG CX LIU JH
Citation
Yy. Ku et al., AN EFFICIENT SYNTHESIS OF DES-N-METHYL-N-ACETYL ERYTHROMYCIN DERIVATIVES VIA THE N-OXIDE, Bioorganic & medicinal chemistry letters, 7(9), 1997, pp. 1203-1206
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
9
Year of publication
1997
Pages
1203 - 1206
Database
ISI
SICI code
0960-894X(1997)7:9<1203:AESODE>2.0.ZU;2-#
Abstract
An efficient synthesis of des-N-methyl-N-acetyl erythromycin derivativ es has been developed, it involves the Polonovsky reaction of erythrom ycin N-oxide derivatives. The reaction conditions have been establishe d so that the desired products can be prepared in high quality and in good yields. This provides a convenient way to prepare des-N-methyl-N- acetylerythromycin-based macrolides. (C) 1997 Elsevier Science Ltd.