Peripheral non-cutaneous T-cell lymphomas. A clinicopathologic study of 29cases

BACKGROUND: To analyze peripheral non-cutaneous T-cell lymphomas (NC-TCL) a nd to test the significance of the IPI. PATHIENS AND METHODS: Twenty-nine consecutive patients diagnosed with NC-TC L according to the REAL classification. RESULTS: At diagnosis were common: 8 symptoms (21%), stage III/IV (55%), hi gh LDH level (55%) and extranodal involvement (79%). Twelve (48%) patients achieved complete remission. The IPI identified groups of patients with dif ferent response to therapy and survival, CONCLUSIONS: NC-TCL with high or high-intermediate IPI had a short survival if treated with CHOP.