Preparation of N-alkylated 5-oxo-3-carboxamyl-1,4-thiazinanes on solid support

Authors
Mortezaei, R Ida, S Campbell, DA
Citation
R. Mortezaei et al., Preparation of N-alkylated 5-oxo-3-carboxamyl-1,4-thiazinanes on solid support, MOL DIVERS, 4(2), 1998, pp. 143-148
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
MOLECULAR DIVERSITY
ISSN journal
13811991 → ACNP
Volume
4
Issue
2
Year of publication
1998
Pages
143 - 148
Database
ISI
SICI code
1381-1991(1998)4:2<143:PON5OS>2.0.ZU;2-H
Abstract
A general method was developed to generate six-membered cyclic thiazinanes on solid support. Three diversity sites were introduced into this scaffold using primary amines, aldehydes, and 2-bromoalkanoic acids. The methodology to prepare individual cyclic thiazinanes as well as combinatorial librarie s of these compounds is described.