Recurrent multifocal demyelinating neuropathy with febrile illness and IgGsubset deficiency

We describe a unique syndrome of recurrent multifocal demyelinating motor g reater than sensory deficits in cranial and peripheral nerve distributions with rapid, spontaneous improvement. Three patients presented with episodes over a period of 7 to 24 years, largely accompanied by febrile illness. Va riably decreased IgG1 and IgG3 subclass levels were found. We postulate an immune-mediated process based upon the clinical presentation and presence o f decreased IgG subclass levels.