The double-exchange model for thr Mn oxides with orbital degeneracy is stud
ied with including on-site Coulomb repulsion, Jahn-Teller (J-T) coupling, a
nd doping-induced disorder. In the strong interaction limit, it is mapped o
nto a single-band Anderson model, in which all scattering mechanisms can be
treated on an equal footing. We show that the spin and J-T disorders lead
to a metal-insulator transition (MIT) only at low carrier density. The MIT
observed in samples with 0.2 less than or equal to x < 0.5 can be explained
by further including the disorder effect of cation size mismatch. An insta
bility against phase separation is also found in the paramagnetic phase in
systems with large cation size mismatch.