Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-1 protease

Authors
Min, BS Jung, HJ Lee, JS Kim, YH Bok, SH Ma, CM Nakamura, N Hattori, M Bae, K
Citation
Bs. Min et al., Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-1 protease, PLANTA MED, 65(4), 1999, pp. 374-375
Citations number
12
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
65
Issue
4
Year of publication
1999
Pages
374 - 375
Database
ISI
SICI code
0032-0943(199905)65:4<374:IEOTFC>2.0.ZU;2-9
Abstract
The methanol extracts of the leaves of Crataegus pinnatifida showed potent inhibitory activities against HIV-1 protease at a concentration of 100 mu g /ml. The subsequent fractionation and isolation of the extract gave two act ive compounds. Their structures were identified as uvaol (1) and ursolic ac id (2) by spectral data, These active compounds inhibit HIV-1 protease with IC50 values of 5.5 and 8.0 mu M, respectively.