ALCOHOL AND THE BRAIN

Evidence grows that Korsakoff's psychosis and alcoholic dementia are p arts of one disorder and that thiamine deficiency has a role. The neur onal basis of withdrawal hyperexcitability is being specified but evid ence for kindling is still limited. Support grows for a role of endoge nous opioids in the explanation of alcohol dependence. Fascinating ani mal models of Type II alcoholism suggest that serotonergic deficiency contributes but this has yet to lead to convincing treatments.