Human gastrointestinal tolerance to D-tagatose

Citation
B. Buemann et al., Human gastrointestinal tolerance to D-tagatose, REGUL TOX P, 29(2), 1999, pp. S71-S77
Citations number
6
Categorie Soggetti
Pharmacology & Toxicology
Journal title
REGULATORY TOXICOLOGY AND PHARMACOLOGY
ISSN journal
02732300 → ACNP
Volume
29
Issue
2
Year of publication
1999
Part
2
Supplement
S
Pages
S71 - S77
Database
ISI
SICI code
0273-2300(199904)29:2<S71:HGTTD>2.0.ZU;2-S
Abstract
D-Tagatose is a stereoisomer of D-fructose which is poorly absorbed in the small intestine and may, therefore, have potential as a reduced calorie bul k sweetener. However, one of the major limitations is the use of malabsorbe d sugars is that their consumption may be associated with gastric discomfor t. This is due to the osmotic impact of the sugar molecules remaining in th e gut lumen for a prolonged period. We have performed a series of studies i n which gastrointestinal symptoms have been recorded after the consumption of 29 or 30 g of D-tagatose. Nausea and diarrhea were reported with an inci dence of 15.1 and 31.5%, respectively, in 73 healthy young male subjects in a screening study. Increased flatulence after D-tagatose was frequently re ported in all the studies and the flatulence did not decline during a 15-da y period with intake of 30 g in one dose daily. In most cases, symptoms wer e reported as light or moderate, However, the results suggest that 30 g tak en at one time may be above the dose which should be recommended for ordina ry use. (C) 1999 Academic Press.