The effect of flow reversal on permeate flux in cross-flow ultrafiltration
of bovine serum albumin (BSA) has been investigated experimentally. BSA is
a well-studied model solute in membrane filtration known for its fouling an
d concentration polarization capabilities. Ultrafiltration experiments were
performed with BSA feed solutions in a hollow-fiber membrane module. The B
SA feed concentrations ranged from 0.01 to 5 wt% and were ultrafiltered at
a transmembrane pressure of 20 psia. Permeate flux was determined both with
and without the use of flow reversal for each concentration. The experimen
tal results indicate that under flow reversal conditions, the permeate flux
is enhanced significantly when compared with runs without flow reversal. T
he effect of flow reversal on flux enhancement is very pronounced for dilut
e BSA solutions.