Topical anti-inflammatory activity of human recombinant epidermal growth factor

Citation
A. Casaco et al., Topical anti-inflammatory activity of human recombinant epidermal growth factor, SKIN PH APP, 12(1-2), 1999, pp. 79-84
Citations number
21
Categorie Soggetti
da verificare
Journal title
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY
ISSN journal
14222868 → ACNP
Volume
12
Issue
1-2
Year of publication
1999
Pages
79 - 84
Database
ISI
SICI code
1422-2868(199901/04)12:1-2<79:TAAOHR>2.0.ZU;2-I
Abstract
The topical anti-inflammatory activity of epidermal growth factor (EGF) was evaluated in inflammation models induced by 12-O-tetradecanoylphorbol-13-a cetate, croton oil and arachidonic acid. When EGF (1.5, 3 or 6 mu g/ear) wa s coapplied with each inflammatory agent, there was a dose-related decrease in inflammation as assessed by ear punch weights, myeloperoxidase activity as well as by histopathological studies. The precise anti-inflammatory act ion of EGF is yet unclear, but we believe that interference with arachidoni c acid metabolism may play an important role.