Synthesis of alpha-arylalkylamines by addition of Grignard reagents to N-(diethoxyphosphoryl)aldimines

Authors
Zwierzak, A Napieraj, A
Citation
A. Zwierzak et A. Napieraj, Synthesis of alpha-arylalkylamines by addition of Grignard reagents to N-(diethoxyphosphoryl)aldimines, SYNTHESIS-S, (6), 1999, pp. 930-934
Citations number
25
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
6
Year of publication
1999
Pages
930 - 934
Database
ISI
SICI code
0039-7881(199906):6<930:SOABAO>2.0.ZU;2-K
Abstract
Addition of organomagnesium bromides to N-(diethoxyphosphoryl) aldimines 1 carried out in tetrahydrofuran at 20-25 degrees C affords diethyl N-alkyl-p hosphoramidates 2a-w in high yields and spectroscopic purity. Deprotection of the latent amino groups in 2 results in the formation of alpha-arylalkyl amine hydrochlorides 3a-w.