A. Zwierzak et A. Napieraj, Synthesis of alpha-arylalkylamines by addition of Grignard reagents to N-(diethoxyphosphoryl)aldimines, SYNTHESIS-S, (6), 1999, pp. 930-934
Addition of organomagnesium bromides to N-(diethoxyphosphoryl) aldimines 1
carried out in tetrahydrofuran at 20-25 degrees C affords diethyl N-alkyl-p
hosphoramidates 2a-w in high yields and spectroscopic purity. Deprotection
of the latent amino groups in 2 results in the formation of alpha-arylalkyl
amine hydrochlorides 3a-w.