Synthesis and applications of a fluorous THP protective group

Authors
Wipf, P Reeves, JT
Citation
P. Wipf et Jt. Reeves, Synthesis and applications of a fluorous THP protective group, TETRAHEDR L, 40(25), 1999, pp. 4649-4652
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
25
Year of publication
1999
Pages
4649 - 4652
Database
ISI
SICI code
0040-4039(19990618)40:25<4649:SAAOAF>2.0.ZU;2-T
Abstract
A recyclable fluorous labeled THP protecting group has been developed that allows for simple purification of small molecules by liquid-liquid extracti on with FC-72/MeCN, and of larger or more polar molecules by solid phase ex traction with fluorous reverse phase silica gel. In addition, we report a n ew glycosylation method which uses the Cp2ZrCl2-AgClO4 reagent system to ac tivate an anomeric sulfoxide. (C) 1999 Elsevier Science Ltd. All rights res erved.