A mild and efficient method to obtain fully t-butyl type protected alcohols
based on the alkylation of Fmoc amino alcohols with the "polymeric dipheny
ldiazomethane" 1 followed by standard Fmoc solid phase synthesis is present
ed. The resulting peptidyl benzhydryl ethers 3 can be cleaved with 1 - 2% t
rifluoroacetic acid in methylene chloride to yield the protected peptide al
cohols. (C) 1999 Elsevier Science Ltd. All rights reserved.