Synthesis of 4 ',8-dihydroxyisoflavon-7-yl alpha-D-arabinofuranoside

Authors
Citation
M. Shiozaki, Synthesis of 4 ',8-dihydroxyisoflavon-7-yl alpha-D-arabinofuranoside, TETRAHEDR-A, 10(8), 1999, pp. 1477-1482
Citations number
12
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
8
Year of publication
1999
Pages
1477 - 1482
Database
ISI
SICI code
0957-4166(19990423)10:8<1477:SO4'A>2.0.ZU;2-H
Abstract
4',8-Dihydroxyisoflavon-7-yl alpha-D-arabinofuranoside 1 (A-76202), which i s a strong alpha-glucosidase I and II inhibitor, was synthesized by the gly cosylation of 2,3,5-tri-O-benzyl-alpha-D-arabinofuranosyl bromide 2 and the lithium salt of 4',8-diallyloxy-7-hydroxyisoflavone 4, and successive depr otection of allyl groups and benzoyl esters of the glycosylated product 5. (C) 1999 Elsevier Science Ltd. All rights reserved.