Vv. Dunina et al., A resolution of the monodentate P*-chiral phosphine PBu(t)C6H4Br-4 and itsNMR-deduced absolute configuration, TETRAHEDR-A, 10(8), 1999, pp. 1483-1497
Both enantiomers of the monodentate phosphine (PBuC6H4Br)-C-t-4 were obtain
ed in an enantiopure state by chromatographic separation of their diastereo
meric adducts with a new homochiral ortho-palladated resolving agent derive
d from alpha-tert-Bu-substituted tertiary benzylamine. The conformation of
the palladacycle and the absolute configuration of the phosphine were deter
mined using TH NMR spectroscopy (including NOE technique) and confirmed by
an X-ray diffraction study of both diastereomeric complexes. The enantiomer
s of the resolved phosphine were displaced from the individual diastereomer
s of the palladium(II) complexes with recovery of the starting resolving ag
ent, and trapped in the form of binuclear coordination complexes of palladi
um(II). (C) 1999 Published by Elsevier Science Ltd. All rights reserved.