Radical cyclisation approach for the first synthesis and determination of absolute stereochemistry of discosiolide from diacetone glucose (vol 10, pg869, 1999)

Authors
Sharma, GVM Krishnudu, K
Citation
Gvm. Sharma et K. Krishnudu, Radical cyclisation approach for the first synthesis and determination of absolute stereochemistry of discosiolide from diacetone glucose (vol 10, pg869, 1999), TETRAHEDR-A, 10(8), 1999, pp. 1625
Citations number
17
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
8
Year of publication
1999
Database
ISI
SICI code
0957-4166(19990423)10:8<1625:RCAFTF>2.0.ZU;2-#
Abstract
By the adoption of a regio- and stereoselective intramolecular radical cycl isation reaction onto a chiron derived from diacetone glucose, the crucial cis-fused bicyclo[3.3.0]octane system was made and utilized for the first s ynthesis of discosiolide 1, thereby establishing the absolute stereochemist ry of the natural product. (C) 1999 Elsevier Science Ltd. All rights reserv ed.