M. Nakakura et al., PROLONGATION OF ANTIDIURETIC RESPONSE TO DESMOPRESSIN ACETATE BY IONTOPHORETIC TRANSDERMAL DELIVERY IN RATS, Biological & pharmaceutical bulletin, 20(5), 1997, pp. 537-540
An iontophoretic drug delivery system was compared with intranasal, or
al and subcutaneous delivery from a standpoint of the prolongation of
the antidiuretic response to desmopressin acetate (DDAVP) in diabetes
insipidus rats. Iontophoretic delivery was comparable to the nasal rou
te at a dose about five times higher than the nasal route dose, and wa
s 2 to 3 times as effective as the oral route. Effect of dose and dura
tion of current application on the prolongation of the response to DDA
VP was also investigated in order to find the effectiveness of the ion
tophoresis. The antidiuretic response to DDAVP delivered by iontophore
sis indicated a dose-dependent prolongation and,vas prolonged up to ab
out 14 h with the increase of the duration of current application; whe
n a pulsed direct current at 0.1 mA was passed for about 1 h, the resp
onse to DDAVP was prolonged for about 9 h. DDAVP in the anodic donor s
teeply decreased with the application for I h, and then gradually decr
eased. We suggest that the antidiuretic response to DDAVP can be effec
tively controlled by regulating the absorption of DDAVP at the short-t
erm iontophoresis rather than prolonged treatment.