5-HT1P receptor-mediated slow depolarization in neurons of guinea pig inferior mesenteric ganglion

Authors
Wang, LC Cai, SR Huang, ZX Shao, QL Ma, RC
Citation
Lc. Wang et al., 5-HT1P receptor-mediated slow depolarization in neurons of guinea pig inferior mesenteric ganglion, ACT PHAR SI, 20(6), 1999, pp. 505-508
Citations number
11
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ACTA PHARMACOLOGICA SINICA
ISSN journal
02539756 → ACNP
Volume
20
Issue
6
Year of publication
1999
Pages
505 - 508
Database
ISI
SICI code
0253-9756(199906)20:6<505:5RSDIN>2.0.ZU;2-G
Abstract
AIM: To study the effects of several 5-hydroxy-tryptamine (5-HT) receptor s ubtype antagonists on 5-HT-induced depolarization and the effects of 5-HTIP receptor agonist on the membrane potential in the neurons of guinea pig in ferior mesenteric ganglion (IMG). METHODS: Intracellular recordings were ma de from neurons of the isolated guinea pig IMG. RESULTS: Cyproheptadine (5- HT1/2 antagonist 10 mu mol . L-1, n = 7) and BRL 24924 (5-HTIP antagonist 1 0 mu mol . L-1, n = 19) reversibly suppressed 5-HT slow response; pressure ejection of MCPP(5-HTIP agonist 10 mmol . L-1) induced a slow depolarizatio n in most of 5-HT sensitive neurons (10/14). CONCLUSION: 5-HT-induced slow depolarization is mediated by 5-HTIP receptor.