Angiotensin-II receptor antagonists: Their place in therapy

Angiotensin-ll receptor antagonists (or blockers) are a newer class of anti hypertensive agents. These drugs are selective for angiotensin II (type 1 r eceptor); unlike angiotensin-converting enzyme inhibitors,they do not inhib it bradykinin metabolism or enhance prostaglandin synthesis. Angiotensin-ll receptor antagonists are well tolerated. Cough occurs much less often with these agents than with angiotensin-converting enzyme inhibitors, and they do not adversely affect lipid profiles or cause rebound hypertension after discontinuation. Clinical trials indicate that angiotensin-II receptor anta gonists are effective and safe in the treatment of hypertension. Their use in congestive heart failure and renal diseases under investigation.