B. Cestaro et al., FREE-RADICALS, ATHEROSCLEROSIS, AGING AND RELATED DYSMETABOLIC PATHOLOGIES - BIOCHEMICAL AND MOLECULAR ASPECTS, European journal of cancer prevention, 6, 1997, pp. 25-30
In human ageing and with many pathologies correlated to the senile fun
ctional decay of cells, membrane damage often occurs in some organ or
tissue, which provokes lipid peroxidation in the membrane and accelera
tes the disorder in structure and function of the membrane, When lipid
peroxides accumulate sufficiently, they leak from the organ or tissue
into the bloodstream and increase the lipid peroxide level in blood l
ipoproteins, The increased lipid peroxides in the blood attack the blo
od vessel and promote atherogenesis, This paper describes the possible
involvement of free radicals in this damage, both to tissues and to b
lood vessels, which contributes to the senile functional decay of the
tissues.