Dietary recommendations evolved from instructions directed at preventi
on of starvation diseases to the level of intake of essential nutrient
s that are adequate to meet the known nutrient needs of practically al
l healthy persons, Vitamin requirements have been modified various tim
es over the years and there are still differences in recommended intak
es in different countries, A debate on optimal vitamin intake is ongoi
ng, based on the concepts of deficiency, sufficiency and hypothetical
identification of a range within which a further biological advantage
can be expected, In establishing appropriate criteria for food and nut
rient intakes, additional studies are warranted on the physiological i
nteractions between nutrients and non-nutrients and on many other fact
ors such as genetic determinants and lifestyle which could interfere w
ith disease prevention.