Acute myeloid leukemia M2 and t(8;21)(q22;q22) with an unusual phenotype: myeloperoxidase (+), CD13(-), CD14(-), and CD33(-)

Authors
Vela, JAG Martin, M Delgado, I Alonso, LG Monteserin, MC Benito, L Somolinos, N Ona, F
Citation
Jag. Vela et al., Acute myeloid leukemia M2 and t(8;21)(q22;q22) with an unusual phenotype: myeloperoxidase (+), CD13(-), CD14(-), and CD33(-), ANN HEMATOL, 78(5), 1999, pp. 237-240
Citations number
14
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
ANNALS OF HEMATOLOGY
ISSN journal
09395555 → ACNP
Volume
78
Issue
5
Year of publication
1999
Pages
237 - 240
Database
ISI
SICI code
0939-5555(199905)78:5<237:AMLMAT>2.0.ZU;2-L
Abstract
Cases of myeloid surface antigen-negative acute myeloid leukemia (AML) are rare. We describe the morphological, cytochemical, immunologic, and cytogen etic features of two patients with AML with maturation (FAB M2) and the phe notype MPO +, CD13 (-), CD33(-), CD56(+). Cytogenetic studies demon strated t(8;21)(q22;q22). These findings suggest an association between the lack o f CD13 and CD33 in myeloperoxidase-positive AML and the presence of t(8;21) .