Re-evaluation of 3-bromopropyl triflate as the percursor in the preparation of 3-[F-18]fluoropropyl bromide

We re-evaluated 3-bromo-1-trifluoromethanesulfonyloxypropane (3-bromopropyl triflate, 1) as the precursor for the preparation of the fluorine-18 label ed compound 2 by reoptimizing fluorine-18 incorporation reaction conditions (120 degrees C) and developing a method to inactivate the unreacted trifla te precursor (water treatment). This new reaction condition enabled us to p repare 3-[F-18]fluoropropyl bromide (2) in high yield. It was used for the synthesis of a N-fluoropropyl derivative such as N-(3-[F-18]fluoropropyl)sp iperone ([F-18]FPSP, 3) with high chemical purity. (C) 1999 Elsevier Scienc e Ltd. All rights reserved.