Clusterin prevents aggregation of neuropeptide 106-126 in vitro

Authors
McHattie, S Edington, N
Citation
S. Mchattie et N. Edington, Clusterin prevents aggregation of neuropeptide 106-126 in vitro, BIOC BIOP R, 259(2), 1999, pp. 336-340
Citations number
24
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X → ACNP
Volume
259
Issue
2
Year of publication
1999
Pages
336 - 340
Database
ISI
SICI code
0006-291X(19990607)259:2<336:CPAON1>2.0.ZU;2-0
Abstract
The prion/amyloid neuropeptide 106-126 spontaneously aggregates to form fib rillar structures in vitro. The aggregation in vitro could be prevented in a dose-related manner by clusterin, and the specificity of this action was confirmed by reversal with antibody to clusterin. The relevance of these ob servations is discussed in relation to previous observations that clusterin and PrPBSE colocalise in naturally occurring cases of BSE. (C) 1999 Academ ic Press.