Stimulation of cellular XTT reduction by cytochrome oxidase inhibitors

Authors
Kunimoto, S Nosaka, C Takeuchi, T
Citation
S. Kunimoto et al., Stimulation of cellular XTT reduction by cytochrome oxidase inhibitors, BIOL PHAR B, 22(6), 1999, pp. 660-661
Citations number
6
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
09186158 → ACNP
Volume
22
Issue
6
Year of publication
1999
Pages
660 - 661
Database
ISI
SICI code
0918-6158(199906)22:6<660:SOCXRB>2.0.ZU;2-O
Abstract
XTT reducing activity by CHO and L1210 cells was found to be stimulated by the presence of cytochrome oxidase inhibitors such as NaN3 or KCN. Among th e other respiratory chain inhibitors, antimycin A (a complex III inhibitor) and chlorpromazine inhibited cellular XTT reduction, and rotenone and malo nate showed slight inhibition and no effect,respectively. It is suggested t hat XTT reduction is coupled with the respiratory chain via cytochrome, whi ch is located between complexes III and IV (cytochrome oxidase).