EEG correlates of methylphenidate response among children with ADHD: A preliminary report

Background: Recent electrophysiologic studies have found fairly consistent differences between children with attention-deficit/hyperactivity disorder (ADHD) and age-matched control subjects. The present study examined electro encephalogram (EEG) changes associated with a double blind, placebo-control led administration of methylphenidate among children with ADHD. Methods: Subjects were 10 children, ages 8 to 13, with a primary diagnosis of ADHD. Brain electrical activity was recorded with 7 electrodes in the fr ontal, central, and midline areas during baseline and cognitive activation conditions. Results: Repeated-measures ANOVAs indicate that children exhibiting a posit ive medication response had reductions of theta and alpha as well as increa sed beta in the frontal regions, while nonresponders showed the apposite pa ttern (p < .05). Significant correlations between improvement on a vigilanc e task and changes in beta activity in the frontal electrodes emerged as we ll: Conclusions: These preliminary findings indicate that there are different e lectrophysiologic correlates to methylphenidate among ADHD children who are medication responders and nonresponders. (C) 1999 Society of Biological Ps ychiatry.