Antihypertensive effect of insulin in the zucker diabetic fatty (ZDF) rat,an animal model for non-insulin dependent diabetes mellitus with insulin resistance
M. Kawaguchi et al., Antihypertensive effect of insulin in the zucker diabetic fatty (ZDF) rat,an animal model for non-insulin dependent diabetes mellitus with insulin resistance, BIOMED RES, 20(1), 1999, pp. 57-59
We investigated an antihypertensive effect of insulin in aged ZDF rat (24 w
eeks) in which insulin resistance is highly developed. Insulin treatment ca
used no change in plasma glucose levels but considerably decreased blood pr
essure, which was accompanied by an increase in plasma NO metabolites (NOx)
in these animals. These findings suggest that NO production may be involve
d in the antihypertensive effect of insulin in the aged ZDF rat, in which i
nsulin resistance had been established.