Binding and catalysis by yeast aldose reductase: A substrate-analog approach with new aldose derivatives

Authors
Hadwiger, P Mayr, P Tauss, A Stutz, AE Nidetzky, B
Citation
P. Hadwiger et al., Binding and catalysis by yeast aldose reductase: A substrate-analog approach with new aldose derivatives, BIOORG MED, 9(12), 1999, pp. 1683-1686
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
12
Year of publication
1999
Pages
1683 - 1686
Database
ISI
SICI code
0960-894X(19990621)9:12<1683:BACBYA>2.0.ZU;2-7
Abstract
5-Deoxy-D-xylofuranose derivatives and a range of new 5,6-dideoxy analogs o f D-glucofuranose bearing azido or fluoro substituents were synthesised and employed as substrates of the NADH-dependent aldehyde reduction catalysed by yeast aldose reductase. In terms of catalytic efficiencies, these produc ts proved to be superior to the parent compounds. (C) 1999 Elsevier Science Ltd. All rights reserved.