Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes

Authors
Wender, PA Lippa, B Park, CM Irie, K Nakahara, A Ohigashi, H
Citation
Pa. Wender et al., Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes, BIOORG MED, 9(12), 1999, pp. 1687-1690
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
12
Year of publication
1999
Pages
1687 - 1690
Database
ISI
SICI code
0960-894X(19990621)9:12<1687:SBOBAT>2.0.ZU;2-C
Abstract
Designed bryostatin analogues are assayed for binding affinity to individua l cysteine rich domains of several protein kinase C (PKC) isozymes. These a nalogues exhibit significant selectivity for the PKC delta-C1B peptide in t erms of absolute affinity and the PKC delta-C1A peptide in terms of relativ e affinity when compared to phorbol-12,13-dibutyrate. (C) 1999 Elsevier Sci ence Ltd. All rights reserved.