Picking the S-1, S-1 ' and S-2 ' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors

Authors
Hanessian, S Bouzbouz, S Boudon, A Tucker, GC Peyroulan, D
Citation
S. Hanessian et al., Picking the S-1, S-1 ' and S-2 ' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors, BIOORG MED, 9(12), 1999, pp. 1691-1696
Citations number
34
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
12
Year of publication
1999
Pages
1691 - 1696
Database
ISI
SICI code
0960-894X(19990621)9:12<1691:PTSS'A>2.0.ZU;2-D
Abstract
A series of acyclic hydroxamic acids harboring strategically placed alpha-a rylsulfonamido and thioether groups was synthesized and found to be potent inhibitors of various MMPs. An unprecedented cleavage of t-butyl hydroxamat es to hydroxamic acids was found. (C) 1999 Elsevier Science Ltd. All rights reserved.