Synthesis and evaluation of 1-position-modified inositol 1,4, 5-trisphosphate analogs

Authors
Inoue, T Kikuchi, K Hirose, K Iino, M Nagano, T
Citation
T. Inoue et al., Synthesis and evaluation of 1-position-modified inositol 1,4, 5-trisphosphate analogs, BIOORG MED, 9(12), 1999, pp. 1697-1702
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
12
Year of publication
1999
Pages
1697 - 1702
Database
ISI
SICI code
0960-894X(19990621)9:12<1697:SAEO1I>2.0.ZU;2-P
Abstract
IP3 analogs were synthesized by the modification of phosphate at the 1-posi tion, and their affinity for the IP3 receptor was analyzed by means of surf ace plasmon resonance measurements. Our results suggest that a hydrophobic and charged moiety linked to this position enhances the affinity for the IP 3 receptor. (C) 1999 Elsevier Science Ltd. All rights reserved.