Photoinduced cross-linking of RNA by cis-Rh(phen)(2)Cl-2(+) and cis-Rh(phen)(phi)Cl-2(+): A new family of light activatable nucleic acid cross-linking agents

Authors
Mohammad, T Chen, CP Guo, PX Morrison, H
Citation
T. Mohammad et al., Photoinduced cross-linking of RNA by cis-Rh(phen)(2)Cl-2(+) and cis-Rh(phen)(phi)Cl-2(+): A new family of light activatable nucleic acid cross-linking agents, BIOORG MED, 9(12), 1999, pp. 1703-1708
Citations number
49
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
12
Year of publication
1999
Pages
1703 - 1708
Database
ISI
SICI code
0960-894X(19990621)9:12<1703:PCORBC>2.0.ZU;2-4
Abstract
The metal complexes, cis-Rh(phen)(2)Cl-2(+) and its more hydrophobic analog cis-Rh(phen)(phi)Cl-2(+), have been shown to photocross-link the 120-base phi 29-encoded pRNA. Primer extension on the cis-Rh(phen)(phi)Cl-2(+)-photo cross-linked RNA revealed that guanines are responsible for the interstrand cross-links. (C) 1999 Elsevier Science Ltd. Ail rights reserved.