Infrequent germ-line mutation of the E-cadherin gene in Japanese familial gastric cancer kindreds

Authors
Iida, S Akiyama, Y Ichikawa, W Yamashita, T Nomizu, T Nihei, Z Sugihara, K Yuasa, Y
Citation
S. Iida et al., Infrequent germ-line mutation of the E-cadherin gene in Japanese familial gastric cancer kindreds, CLIN CANC R, 5(6), 1999, pp. 1445-1447
Citations number
33
Categorie Soggetti
Oncology
Journal title
CLINICAL CANCER RESEARCH
ISSN journal
10780432 → ACNP
Volume
5
Issue
6
Year of publication
1999
Pages
1445 - 1447
Database
ISI
SICI code
1078-0432(199906)5:6<1445:IGMOTE>2.0.ZU;2-E
Abstract
Germ-line mutation of the E-cadherin gene was reported in familial gastric cancer (FGC) kindreds from New Zealand. Therefore, we analyzed all of the e xons of E-cadherin by PCR-single-strand conformational polymorphism analysi s in 16 patients from 14 Japanese FGC kindreds. However, no germ-line mutat ion was detected, suggesting that a predisposition to FGCs by E-cadherin ge ne mutation is infrequent in Japanese cases.