Interictal spike localization using a standard realistic head model: simulations and analysis of clinical data

Objectives: In this paper realistic and standard realistic head models were applied to neural source localization. Methods: Three different triangulated head structures; the brain, the skull and the scalp were constructed from MRI information of each patient. For e ach subject the exact positions of the electrodes were digitized. Results: The influence of the number of triangles and of the skull conducti vity on the accuracy of the method was tested. The use of a standard realis tic head model instead of spherical models is proposed in cases where detai led MRI information is not available, and the accuracy of this procedure is tested with dipole simulations. These techniques were applied also to EEG signals from 3 patients with focal epilepsy. In all cases the neural activi ty was assumed to be confined to a small portion of cortical tissue, so tha t the neural generator was approximated to a current dipole. The realistic head model localization is discussed on the basis of neuroimaging informati on. Conclusions: We show that the standard realistic head model is two or 3 tim es better than the spherical model for dipole localization and we propose i t as a good alternative to the spherical model for EEG data processing, in cases where full MRI information is not available. (C) 1999 Elsevier Scienc e Ireland Ltd. All rights reserved.