Following concerns over the potential for insect resistance to insecticidal
Bacillus thuringiensis toxins expressed in transgenic plants, there has be
en recent interest in novel biological insecticides. Over the past year the
re has been considerable progress in the cloning of several alternative tox
in genes from the bacteria Photorhabdus luminescens and Xenorhabdus nematop
hilus. These genes encode large insecticidal toxin complexes with little ho
mology to other known toxins.