Al. James et al., Associations between white blood cell count, lung function, respiratory illness and mortality: the Busselton Health Study, EUR RESP J, 13(5), 1999, pp. 1115-1119
An independent association between reduced levels of lung function and incr
eased mortality from nonrespiratory causes has been observed in a number of
studies. Since the total white blood cell count (WBC) has been related to
both death from coronary heart disease and to levels of lung function, the
relationship between these parameters was examined in subjects from the Bus
selton Health Surveys.
Questionnaires regarding respiratory and cardiac illness and smoking habits
were administered and total WBC, forced expiratory volume in one second (F
EV1) and forced vital capacity measured in 2,105 males and 2,186 females at
their initial attendance at a Busselton Health Survey in 1969, 1972 or 197
5. Mortality follow-up to 1995 was completed.
Multiple linear regression showed that smoking, increasing age, reduced FEV
1 (% predicted) and a history of bronchitis were associated with increased
WBC. Reduction of FEV1 (% pred) bg 20%, a history of dyspnoea and an increa
se in WBC of 1,300 cells.mL(-1) were predictive of increased mortality from
all causes or coronary heart disease by approximately 20, 100 and 10% resp
ectively, independent of smoking. Removing WBC from the regression model di
d not significantly change the relationship between FEV1 and mortality.
The study shows that the white blood cell count, forced expiratory volume i
n one second and dyspnoea are independently related to mortality in both ma
les and females and that the effect of forced expiratory volume in one seco
nd on mortality is not explained by the white blood cell count.