Modular PH and C2 domains in membrane attachment and other functions

The pleckstrin homology and C2 domains are modular protein structures invol ved in mediating intermolecular interactions. Although they represent disti nct domains, there are several parallels regarding their function and type of interactions in which they participate. Both domains are stable structur al entities that incorporate variable regions which, in different proteins, can be adapted to perform a specific function through binding to membrane phospholipids or specific protein ligands. A number of recent examples illu strate the function of some of these domains in regulated membrane attachme nt, with an important role in many cellular signalling pathways. (C) 1999 F ederation of European Biochemical Societies.