Laparoscopic lymphadenectomy for gynecologic malignancies

Objective. The purpose of our study was to detail our 5-year experience wit h laparoscopic lymphadenectomy for gynecologic malignancies. Methods. From 11/5/92 to 3/9/98, we performed laparoscopic lymphadenectomie s on 94 patients with various gynecologic malignancies. Pelvic, paraaortic, and combinations of both pelvic and paraaortic lymphadenectomies were perf ormed depending on the primary site of disease and indication for lymph nod e dissection. Data were prospectively collected on all patients. Results. From 11/5/92 to 3/9/98 we performed 94 laparoscopic lymphadenectom ies for gynecologic malignancies. The distribution included 64 patients wit h cervical cancer, 14 with ovarian cancer, 12 with endometrial cancer, 2 wi th fallopian tube cancer, 1 with a uterine malignant mixed mesodermal tumor , and 1 with a metastatic neuroendocrine tumor. Fifty-five patients had onl y pelvic lymph node dissections, 9 patients had paraaortic dissections only , and 30 had both pelvic and paraaortic dissections performed. Among 30 pat ients having laparoscopic lymphadenectomy only, the mean hospital stay was 3.6 days. Included in this group were 19 patients who received postoperativ e neoadjuvant chemotherapy for cervical cancer as inpatients prior to ambul atory radiation therapy. The mean length of stay for this group was 4.6 day s versus 1.7 days for the 11 patients who did not receive postoperative che motherapy (P = 0.0025). The mean number of pelvic nodes was 11.9 (range 0-5 7), with a mean of 4.5 between 11/5/92 and 12/31/95 and a mean of 19.1 from 1/1/96 to 3/9/98. The mean number of paraaortic nodes obtained was 3.7 (ra nge 0-14), with a mean of 3.4 from 11/5/92 to 12/31/95 and a mean of 4.1 fr om 1/1/96 to 3/9/98. A total of 3 patients required conversions to laparoto my. One was for a vascular injury to the vena cava, 1 for a large tumor ext ending to both sidewalls, and the third for removal of densely matted lymph nodes. Conclusions. Laparoscopic lymphadenectomy is a technically feasible procedu re for patients with gynecologic malignancies requiring lymph node dissecti ons, with an acceptable safety profile and nodal yield. The number of nodes obtained increased in direct proportion to operator experience. In additio n, patients may benefit from a decrease in hospital stay compared to conven tional lymphadenectomy via laparotomy. (C) 1999 Academic Press.