Radiotherapy for the treatment of metastatic granulosa cell tumor in the mediastinum: A case report

Objective. We report a case of metastatic ovarian granulosa cell tumor in t he mediastinum with a a-year disease-free interval after treatment with rad iotherapy and review the literature regarding the use of radiotherapy in re current and metastatic granulosa cell tumor. Methods. The patient's medical records, histological slides, and radiologic al films were reviewed. The pertinent references were obtained using a Medl ine search and cross-references. Results. A patient with Stage 1A granulosa cell tumor developed a recurrenc e in the retroperitoneum 10 years after initial surgery. She was treated wi th chemotherapy followed by surgical resection, She subsequently developed metastatic tumor in the mediastinum which responded completely to radiother apy. She has remained disease free for 2 years since the completion of radi otherapy. Conclusion. Radiotherapy is a treatment option that should be considered in localized recurrent or metastatic granulosa cell tumor that is not amenabl e to surgery as it can potentially control the disease for several years. ( C) 1999 Academic Press.