Nasal T-tell lymphoma as a cause of lethal midline granuloma

A case of nasal T-cell lymphoma as a cause of lethal midline granuloma in a 41-year-old woman is described. Primary chemotherapy as management failed, and tumor control was achieved thereafter by local radiotherapy to a dose of 52 Gy. Fourteen months after diagnosis the patient died in multiorgan fa ilure with involvement of her skin,lung and liver. Present studies give str ong evidence that lethal midline granuloma is very often a type of`T-cell l ymphoma that might be caused by Epstein-Barr virus. According to the litera ture our findings support the hypothesis that tumors are best treated by lo cal high-dose irradiation.