T. Hasegawa et al., Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice, INT J IMMUN, 21(5), 1999, pp. 311-323
Hot water extract of Chlorella vulgaris (CVE) is a biological response modi
fier (BRM) which enhances resistance to Listeria monocytogenes through augm
entation of helper T cell type 1 (Th1) responses producing gamma-interferon
(gamma IFN). We show here that oral administration of CVE in mice suppress
ed the production of immunoglobulin (Ig)E against casein antigen accompanie
d by increased gamma IFN and IL-12 mRNA expression. Oral administration of
CVE enhanced Th1 response to casein in the spleen of casein immunized mice.
CVE may be useful for prevention of allergic diseases with a predominant T
h2 response. (C) 1999 International Society for Immunopharmacology. Publish
ed by Elsevier Science Ltd. All rights reserved.