Modeling of supersaturated dissolution data

A recursion equation which relies on the population growth model of dissolu tion is used for the analysis of supersaturated dissolution data. The conce ntration-time data of dissolution experiments are initially transformed to fractions of dose dissolved-generations by adopting an appropriate time int erval as the time step of the recursion equation. A computer program is use d to derive estimates for the maximum fraction of dose dissolved and the fr action of dose remaining in solution at steady state. Good fittings were ob served when this equation was applied to phenytoin and nifedipine supersatu rated dissolution data obtained from literature. (C) 1999 Elsevier Science B.V. All rights reserved.