Gastric enterochromaffin-like-cell tumor with liver and splenic metastases

We report a patient with gastric enterochromaffin-like-cell tumor with live r and splenic metastases. He was 68 years old and presented with major comp laints of epigastric pain and weight loss. Under the diagnosis of gastric c arcinoma with liver metastasis, total gastrectomy with splenectomy and late ral segmentectomy of the liver was performed. Intraoperative findings resul ted in a diagnosis of adenocarcinoma T3N2P0H1, in stage IVa. Histological e xamination of the resected specimens showed a well differentiated neuroendo crine carcinoma (enterochromaffin-like-cell tumor) with liver and splenic m etastasis which demonstrated high-grade lymphatic and vascular invasion. Th ere was no lymph node metastasis. The tumor cells in the stomach, liver and spleen were immunoreactive for chromogranin A and Grimelius-positive. We r eview the literature, as well as presenting this case report.