EFFECT OF SALMONELLA-TYPHOSA LIPOPOLYSACC HARIDE ON ELECTRICAL-ACTIVITY OF NEURONS IN THE MOLLUSK LYMNAEA-STAGNALIS

Effect of Salmonella typhosa lipopolysaccharide on identified neurons in the isolated central nervous system of Lymnaea stagnalis was studie d. The activity of 3-6 neurons was simultaneously intracellularly reco rded using glass microelectrodes. Addition of lipopolysaccharide (40 m u g/ml) to the bath (volume 10 ml) at constant rate of perfusion 3 ml/ min led 8-18 min after to the suppression of activity of buccal neuron s and increase in the spike activity of interneurons which control mus cle contractions in the mantle, pneumostome and limb. The effects pers isted up to 4 h. The results suggest that invertebrates may develop th e pattern oi systemic responses to endotoxins analogous to the complex es of protective responses in vertebrates.