Pediatric glial tumors differ from adult gliomas in several ways that are o
f major therapeutic importance. First, the value of extensive tumor resecti
on, which is controversial for malignant intrinsic brain tumors in adults,
has been confirmed for a variety of childhood brain tumors, such as suprate
ntorial high-grade and low-grade gliomas and infratentorial low-grade gliom
as, ependymomas, and some medulloblastomas. Second, chemotherapy has been f
ound to be effective in improving overall outcome in several childhood brai
n tumors, such as medulloblastoma and supratentorial high-grade glioma, but
has yet to be proven to have a major benefit for adult tumors. In addition
, chemotherapy is increasingly used to delay or avoid radiotherapy in young
children with high-grade and incompletely resected low-grade tumors to avo
id the morbidity of irradiation on the developing nervous system. Third, th
e prognosis for histologically similar tumors is often more favorable in ch
ildren than adults. The present chapter will highlight the unique features
of childhood glial tumors, discuss general principles in the clinical prese
ntation, diagnostic evaluation, and treatment of these tumors, and then foc
us on the surgical management and outcome of the more common types of tumor
s.