C-2-symmetric bisphosphinobioxazoline as a chiral ligand. Highly enantioselective palladium-catalyzed allylic substitutions and formation of P,N,N,P tetradentate palladium (II) complexes

The C-2-symmetric bisphosphinobioxazoline [(S,S)-Phos-Biox] 4 was found to be a highly efficient chiral ligand for Pd-catalyzed enantioselective allyl ic substitution of rac-1,3-diphenyl-2-propenyl acetate with dimethyl malona te and afforded enantioselectivities of up to 97% ee. Moderate enantioselec tivities have been observed in Pd-catalyzed desymmetrizations of cis-1,4-bi s(benzoyloxy)-cyclopent-2-ene (12) with dimethyl malonate (51-78% yield, 38 -58% eel) and N-benzyl-N-methylamine (87% yield, 33% ee) nucleophiles and o f biscarbamate 15 of cis-1,4-dihydroxycyclopent-2-ene (90% yield, 50% ee). A 1:1 molar mixture of(S,S)-Phos-Biox 4 with Pd(CH3CN)(2)Cl-2 and [(eta(3)- C3H5)PdCl](2) afforded the P,N,N,P-tetradentate Pd(II) complexes 19a and 19 b, respectively. The structures of the complexes 19a,b were determined by X -ray analysis. The complex 19a also exhibited high enantioselectivity (86% yield, 92% ee) in allylic substitution of rac-1,3-diphenyl-2-propenyl aceta te with dimethyl malonate.